I wear mesh hair, Slink hands and feet, often wear mesh clothes, but hadn't felt the need to get a mesh body. I'm pretty satisfied with the skin that I have, and don't hang out at places where I wouldn't be wearing any clothes, so that eliminated some of the reasons I'd heard for getting a mesh body. I also have some non-mesh clothes that I still like to wear at times, as well.
Several weeks ago I decided to get a petite sized avatar... for when I'm feeling fae ... and now I have a petite sized mesh body, with a bento head and bento hands. So, I've dipped my toe into the water, so to speak.
I haven't decided yet if I'm going to look for a mesh body for when I'm more normal sized or not yet. I haven't felt pressured yet, or felt any need in terms of not being able to find clothing or accessories for my system body. When I do buy mesh clothes that come with mesh body specific versions as well as the standard sizes, I do keep all of them - I just stick them in an 'extras' folder for the item, so if I do choose to move to a mesh body, I'll already have clothes that I'll be able to wear (I think, anyway)